全文获取类型
收费全文 | 3047篇 |
免费 | 276篇 |
国内免费 | 215篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 6篇 |
妇产科学 | 7篇 |
基础医学 | 73篇 |
口腔科学 | 4篇 |
临床医学 | 305篇 |
内科学 | 1144篇 |
皮肤病学 | 2篇 |
神经病学 | 8篇 |
特种医学 | 436篇 |
外国民族医学 | 4篇 |
外科学 | 289篇 |
综合类 | 516篇 |
预防医学 | 49篇 |
药学 | 164篇 |
中国医学 | 44篇 |
肿瘤学 | 486篇 |
出版年
2024年 | 11篇 |
2023年 | 75篇 |
2022年 | 167篇 |
2021年 | 215篇 |
2020年 | 194篇 |
2019年 | 128篇 |
2018年 | 171篇 |
2017年 | 162篇 |
2016年 | 173篇 |
2015年 | 209篇 |
2014年 | 281篇 |
2013年 | 246篇 |
2012年 | 190篇 |
2011年 | 211篇 |
2010年 | 165篇 |
2009年 | 196篇 |
2008年 | 140篇 |
2007年 | 139篇 |
2006年 | 108篇 |
2005年 | 99篇 |
2004年 | 51篇 |
2003年 | 49篇 |
2002年 | 33篇 |
2001年 | 29篇 |
2000年 | 28篇 |
1999年 | 15篇 |
1998年 | 15篇 |
1997年 | 8篇 |
1996年 | 5篇 |
1995年 | 10篇 |
1994年 | 3篇 |
1993年 | 3篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1990年 | 3篇 |
1989年 | 1篇 |
1985年 | 1篇 |
1983年 | 1篇 |
排序方式: 共有3538条查询结果,搜索用时 0 毫秒
91.
92.
93.
94.
《JACC: Cardiovascular Interventions》2014,7(10):1093-1102
ObjectivesThe aim of this study was to identify clinical, procedural, and angiographic correlates of late/very late drug-eluting stent (DES) thrombosis as well as to determine the clinical outcomes of these events.BackgroundLate/very late DES thromboses are a poorly studied phenomenon, partly due to the relative infrequency of these events, even in large cohort studies.MethodsIn the DESERT (International Drug-Eluting Stent Event Registry of Thrombosis), a retrospective, case-control registry, 492 cases of late/very late definite DES thrombosis from 21 international sites were matched in a 1:1 fashion with controls without stent thrombosis (ST). Controls were matched according to 2 criteria: same enrolling institution and date of initial DES implantation. Baseline and procedural variables were collected, and clinical follow-up was obtained for patients with ST as long as 1 year after the event. Offline quantitative coronary angiography was performed for a subset of 378 case-control pairs.ResultsThe majority of ST events occurred after 1 year (75%) and continued to occur for as long as 7.3 years. The clinical presentation of late/very late ST events was mainly myocardial infarction (66.7% ST-segment elevation myocardial infarction and 22.0% non–ST-segment elevation myocardial infarction); in-hospital mortality was 3.8%. A minority of patients (30%) with ST were receiving dual-antiplatelet therapy at the time of the event. Independent clinical correlates of late/very late ST were younger age, African-American race, current smoking, multivessel disease, longer stented length, overlapping stents, and percutaneous coronary intervention of vein graft lesions. Independent angiographic correlates for late/very late ST were lesions within the left anterior descending artery or a bypass graft, thrombus, and a larger residual diameter stenosis after the initial DES implantation. Despite the large sample of ST cases, all identified correlates of late/very late ST had weak associations with subsequent ST (all odds ratios <2.5).ConclusionsDespite a large sample of ST cases and use of limited matching to maximize the identification of predictive factors associated with late/very late ST, the variables associated with the development of late/very late ST were only weakly predictive of subsequent events. Additionally, a relatively low observed mortality rate of ST in this series may reflect a different pathophysiology of these late/very late events compared with acute/subacute ST. (Drug Eluting Stent Registry of Thrombosis [DESERT]; NCT00812552). 相似文献
95.
目的探讨三维适形放射治疗(Three-dimensional conformal radiotherapy,3DCRT)联合肝动脉化疗栓塞术(hepatic arterial chemoembolization,TACE)治疗中晚期肝癌的可行性及优势。方法选取60例确诊的无手术指征的中晚期肝癌患者,先行TACE,将导管置于肝固有动脉,灌注5-氟脲嘧1 000 mg+羟基喜树碱20 mg,然后用微导管超选肿瘤供血动脉,将超液化碘油10 ml与吡柔比星30 mg制成碘油化疗乳剂,对肿瘤进行栓塞;而后再注入细微颗粒对肿瘤血管进行栓塞,如PVA颗粒或明胶海绵颗粒,造影复查肿瘤供血动脉消失。3~4周后复查上腹部CT、肝肾功能、血常规,如果肿块体积过大,须再次行TACE治疗,待肿块缩小后,再进行3DCRT;TACE平均为3~5次。所有患者均行3DCRT。结果放疗结束1个月后评价疗效,其中完全缓解(CR)11例,部分缓解(PR)34例,无变化(NC)12例,进展(PD)3例,总有效率(CR+PR)为75%,1年生存率80%,2年生存率35%,3年生存率13.3%,死于非肿瘤相关疾病6例(10%),至随访日生存者5例(8.3%)。全组中位生存时间16个月。结论 3DCRT联合TACE治疗中晚期肝癌是一种安全有效的方法,它能更好地杀灭肿瘤细胞、明显提高肿瘤局控率、延长生存期、提高生存质量,是治疗中晚期肝癌理想、有效的一种方法,值得临床推广应用。 相似文献
96.
Ignacio Ferreira-González MD PhD Josep R. Marsal Aida Ribera Gaietà Permanyer-Miralda Bruno García-Del Blanco Gerard Martí Purificación Cascant Mónica Masotti-Centol Xavier Carrillo Josepa Mauri Nuria Batalla Eduard Larrousse Eva Martín Antonio Serra José Ramón Rumoroso Rafael Ruiz-Salmerón Jose M. de la Torre Angel Cequier Jose A. Gómez-Hospital Fernando Alfonso Victoria Martín-YusteManel Sabatè PhD David García-Dorado 《Journal of the American College of Cardiology》2012
97.
98.
99.
Clemens von Birgelen Mounir W.Z. Basalus Kenneth Tandjung K. Gert van Houwelingen Martin G. Stoel J. W. Louwerenburg Gerard C.M. Linssen Salah A.M. Saïd Miep A.W.J. Kleijne Hanim Sen Marije M. Löwik Job van der Palen Patrick M.J. Verhorst Frits H.A.F. de Man 《Journal of the American College of Cardiology》2012
100.
目的:探讨吉西他滨联合奥沙利铂经肝动脉化疗栓塞(transcatheter arterial chemoembolization,TACE)在防治肝癌高危患者术后复发中的价值.方法:回顾性分析肝癌术后复发高危患者120例,88例术后3-6wk接受TACE治疗为TACE组,其中43例采用吉西他滨联合奥沙利铂组成的GEMOX方案(GEMOX组),45例使用传统化疗药物方案(对照组);32例因其他原因未接受TACE治疗作为为单纯手术组.通过6mo、12mo的随访,比较各组6mo、12mo术后复发率.结果:TACE组术后6mo、12mo肝内复发率(20.5%、43.8%)明显低于单纯手术组(37.5%、59.4%),两者均有统计学意义(χ2=6.512、4.573,P<0.05).在TACE组中,GEMOX组6mo术后复发率(11.6%)较对照组(28.9%)低,差异有统计学意义(χ2=4.026,P<0.05),两组12mo术后复发率无明显差异(χ2=0.876,P>0.05);在TACE不良反应中,GEMOX组白细胞减少及恶心、呕吐发生率较对照组低,差异有统计学意义(Z=-2.156、-2.295,P<0.05).结论:对肝癌术后复发高危患者进行预防性TACE有助于减少或延缓术后近期复发率,吉西他滨联合奥沙利铂方案疗效更佳. 相似文献